ALNY AI Stock Analysis – Buy, Hold, or Avoid?
Alnylam Pharmaceuticals, Inc. (ALNY)
Fundamentals
Alnylam Pharmaceuticals (ALNY) operates as a leading biotech firm specializing in RNA interference therapeutics with a strong niche in rare genetic diseases. Despite a compressed valuation reflecting market skepticism, the company has maintained solid revenue growth driven by a premium, specialized product portfolio, though profit margins and earnings remain pressured by substantial R&D investments.
Financial Highlights
- Revenue
- Net Income
- Net Margin (%)
Revenue
66.86% YoY
Q2 2026
Net Income
348.19% YoY
Q2 2026
Net Margin
Q2 2026
Growth Metrics
Revenue Growth YoY
Latest Quarter: Q2 2026
Net Income Growth YoY
Latest Quarter: Q2 2026
Revenue Per Share Growth YoY
Latest Quarter: Q2 2026
EPS Growth YoY
Latest Quarter: Q2 2026
Book Value Per Share Growth YoY
Latest Quarter: Q2 2026
| Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | |
|---|---|---|---|---|---|---|---|---|
| Revenue | 1.3B | 1.2B | 1.1B | 1.2B | 773.7M | 594.2M | 593.2M | 500.9M |
| Revenue Growth YoY | +66.86% | +96.43% | +84.95% | +149.35% | +17.26% | +20.20% | +34.90% | -33.26% |
| Net Income | 164.5M | 206.0M | 186.4M | 251.1M | -66.3M | -57.5M | -83.8M | -111.6M |
| Net Income Growth YoY | +348.19% | +458.38% | +322.56% | +325.05% | -292.43% | +12.82% | +39.24% | -175.51% |
| EPS | $1.23 | $1.55 | $1.41 | $1.91 | -$0.51 | -$0.44 | -$0.65 | -$0.87 |
| EPS Growth YoY | +341.18% | +452.27% | +316.92% | +319.54% | -292.31% | +15.38% | +40.91% | -173.73% |
Profitability Metrics
Technical Analysis
ALNY is currently trading below key moving averages, indicating a bearish bias, yet momentum indicators like the MACD suggest a potential shift toward bullishness. The stock is consolidating within a range, showing signs of slowing down its decline but not yet confirming a sustained reversal. Key technical levels around $287.98 support and $318.3 resistance define the near-term trading range.
No extreme reading
Price in downtrend
Strong trend active
50 below 200 - bearish
Key Technical Values
Price with Moving Averages
50-day, 150-day and 200-day simple moving averages
Relative Strength Index
Momentum oscillator measuring speed and magnitude of price changes
RSI (14)
Earnings
Alnylam Pharmaceuticals (ALNY) operates as a leading biotech firm specializing in RNA interference therapeutics with a strong niche in rare genetic diseases. Despite a compressed valuation reflecting market skepticism, the company has maintained solid revenue growth driven by a premium, specialized product portfolio, though profit margins and earnings remain pressured by substantial R&D investments.
Latest Earnings
Q2 2026 Earnings (Jun 30, 2026)
Earnings Per Share (EPS)
Actual
$1.21
Estimated
$1.63
Surprise
$-0.42
Surprise %
-25.77%
Revenue
Actual
$1.29B
Estimated
$1.32B
Surprise
-$31.18M
Surprise %
-2.36%
Historical Earnings
| Q2 2026 | Q1 2026 | Q4 2025 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | |
|---|---|---|---|---|---|---|---|---|
| Earnings Per Share | ||||||||
| EPS (Actual) | $1.21 | $1.51 | $0.82 | $0.82 | $2.90 | $0.32 | $-0.01 | $0.06 |
| EPS (Estimated) | $1.63 | $0.87 | $1.16 | $1.16 | $0.56 | $-0.54 | $-0.89 | $-0.62 |
| EPS Surprise | -$0.42 | +$0.64 | -$0.34 | -$0.34 | +$2.34 | +$0.86 | +$0.88 | +$0.68 |
| % Diff | -25.8% | +73.2% | -29.3% | -29.3% | +416.9% | +158.9% | +98.9% | +109.7% |
| Revenue | ||||||||
| Revenue (Actual) | $1.29B | $1.17B | $1.1B | $1.1B | $1.25B | $773.69M | $594.19M | $593.17M |
| Revenue (Estimated) | $1.32B | $1.12B | $1.15B | $1.15B | $959.4M | $662.87M | $585.14M | $582.61M |
| Revenue Surprise | -$31.18M | +$51.66M | -$52.08M | -$52.08M | +$289.63M | +$110.82M | +$9.05M | +$10.56M |
| % Diff | -2.4% | +4.6% | -4.5% | -4.5% | +30.2% | +16.7% | +1.5% | +1.8% |
Valuation
Alnylam Pharmaceuticals (ALNY) currently trades at a premium valuation compared to the broader biotech sector, supported by strong revenue growth and solid profitability metrics. Despite recent price target downgrades by some analysts, the consensus remains moderately positive with a potential upside of 40-60% based on intrinsic value estimates, reflecting confidence in its pipeline and market position amid near-term growth concerns.
Valuation Metrics
Price to Earnings
TTM
Price to Sales
TTM
Price to Book
TTM
Enterprise Value to EBITDA
TTM
Enterprise Value to Revenue
TTM
| Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | |
|---|---|---|---|---|---|---|---|---|
| Price to Earnings | 61.18 | 53.37 | 70.51 | 59.69 | -159.85 | -153.42 | -90.50 | -79.03 |
| Price to Sales | 31.07 | 37.67 | 47.93 | 47.99 | 54.66 | 58.93 | 51.01 | 70.60 |
| Price to Book | 29.62 | 40.89 | 66.63 | 256.27 | 168.75 | 303.33 | 451.03 | 1093.10 |
| Enterprise Value to EBITDA | 162.10 | 142.97 | 171.73 | 201.09 | 2331.78 | 3205.39 | -227.35 | -613.42 |
| Enterprise Value to Revenue | 30.73 | 37.30 | 47.59 | 47.84 | 56.76 | 61.79 | 54.01 | 73.85 |
Sentiment & Analyst Ratings
Alnylam Pharmaceuticals (ALNY) sentiment is currently mixed due to a sharp stock decline after a disappointing Q2 2026 revenue miss and lowered full-year guidance, despite strong earnings per share and robust revenue growth in key products. Analysts broadly maintain a moderate buy consensus, reflecting confidence in Alnylam's long-term pipeline and market position, while social sentiment mirrors the recent cautious tone with concerns around product adoption and guidance normalization.
Analyst Recommendations
Risk Assessment
Alnylam Pharmaceuticals (ALNY) currently presents a moderate financial risk profile supported by strong liquidity ratios and manageable leverage, although recent valuation pressures reflect clinical trial uncertainties and competitive risks. While liquidity is robust and debt levels are improving, key risks include regulatory milestones, pipeline trial outcomes, and market adoption challenges for its new drug. Analysts maintain a moderately positive outlook with cautious optimism given the recent share price volatility and reduced sales guidance.
Liquidity & Solvency
Current Ratio
Latest Quarter: Q2 2026
Quick Ratio
Latest Quarter: Q2 2026
Debt-to-Equity
Latest Quarter: Q2 2026
Debt-to-Assets
Latest Quarter: Q2 2026
| Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | |
|---|---|---|---|---|---|---|---|---|
| Liquidity Metrics | ||||||||
| Current Ratio | 3.05 | 3.13 | 2.76 | 2.54 | 2.80 | 3.04 | 2.78 | 2.75 |
| Quick Ratio | 2.99 | 3.06 | 2.71 | 2.49 | 2.75 | 2.98 | 2.71 | 2.69 |
| Solvency Metrics | ||||||||
| Debt-to-Equity | 0.94 | 1.18 | 1.62 | 5.59 | 10.93 | 23.58 | 40.89 | 84.26 |
| Debt-to-Assets | 0.23 | 0.25 | 0.26 | 0.27 | 0.60 | 0.65 | 0.65 | 0.65 |
Liquidity Assessment
Current Ratio: 3.05(Strong)
Quick Ratio: 2.99(Strong)
The company has strong liquidity with sufficient short-term assets to cover liabilities.
Solvency Assessment
Debt-to-Equity: 0.94(Moderate)
Debt-to-Assets: 0.23(Low)
The company maintains a balanced capital structure with manageable debt levels.
Frequently Asked Questions about ALNY
AI Answers: Common Questions About ALNY
Get AI-powered answers to the questions investors ask most about Alnylam Pharmaceuticals, Inc.
ALNY is a good buy for long-term investors due to its leadership in RNAi therapeutics, steady mid-20% revenue growth, and promising pipeline. However, the current P/E ratio of 48.97 and recent guidance cuts suggest cautious entry, preferably on technical support near $288 or after positive catalysts.
Selling is not broadly recommended unless near-term technical breakdown below $288 support occurs or clinical setbacks arise. The stock’s strong fundamentals and pipeline warrant holding through volatility for most investors.
Key risks include clinical trial failures, regulatory delays, slower adoption of new products like Amvuttra, and valuation pressures from a premium P/E and EV/EBITDA multiples relative to biotech peers.
Analyst consensus price targets imply 40-60% upside from current levels near $272, with resistance around $310-$318 as key technical targets.
ALNY trades at a premium valuation with a P/E of 48.97 and elevated EV/EBITDA reflecting high growth expectations. Valuation is below historical peaks but above sector medians, justified by rapid revenue growth (~65% YoY) and improving earnings.
Fundamentals show steady revenue growth driven by specialized RNAi products, healthy gross margins above 70%, but negative net margins due to high R&D and SG&A expenses. Liquidity is strong with current ratio above 3.1 and improving debt metrics.
Technically, the stock is below key moving averages indicating bearish trend, but MACD bullish crossover and neutral RSI suggest potential momentum building. Support at $288 and resistance near $310-$318 define the near-term range.
Upcoming catalysts include clinical trial readouts, new indication approvals, and acceleration in sales growth of core RNAi therapies, which could drive re-rating and positive sentiment shifts.
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