ALNY AI Stock Analysis – Buy, Hold, or Avoid?

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Alnylam Pharmaceuticals, Inc. (ALNY)

Fundamentals

Essentia
Essentia
Fundamental Analysis
NEUTRAL

Alnylam Pharmaceuticals (ALNY) operates as a leading biotech firm specializing in RNA interference therapeutics with a strong niche in rare genetic diseases. Despite a compressed valuation reflecting market skepticism, the company has maintained solid revenue growth driven by a premium, specialized product portfolio, though profit margins and earnings remain pressured by substantial R&D investments.

Financial Highlights

Q2 2025Q3 2025Q4 2025Q1 2026Q2 2026-$450.0M$0$450.0M$900.0M$1.4BRevenue & Net Income ($)-9%0%9%18%27%Net Margin (%)
  • Revenue
  • Net Income
  • Net Margin (%)

Revenue

$1.29B

66.86% YoY

Q2 2026

Net Income

$164.49M

348.19% YoY

Q2 2026

Net Margin

12.74%

Q2 2026

Growth Metrics

Revenue Growth YoY

66.86%

Latest Quarter: Q2 2026

Net Income Growth YoY

348.19%

Latest Quarter: Q2 2026

Revenue Per Share Growth YoY

62.39%

Latest Quarter: Q2 2026

EPS Growth YoY

341.18%

Latest Quarter: Q2 2026

Book Value Per Share Growth YoY

425.90%

Latest Quarter: Q2 2026

 Q2 2026Q1 2026Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024
Revenue1.3B1.2B1.1B1.2B773.7M594.2M593.2M500.9M
Revenue Growth YoY+66.86%+96.43%+84.95%+149.35%+17.26%+20.20%+34.90%-33.26%
Net Income164.5M206.0M186.4M251.1M-66.3M-57.5M-83.8M-111.6M
Net Income Growth YoY+348.19%+458.38%+322.56%+325.05%-292.43%+12.82%+39.24%-175.51%
EPS$1.23$1.55$1.41$1.91-$0.51-$0.44-$0.65-$0.87
EPS Growth YoY+341.18%+452.27%+316.92%+319.54%-292.31%+15.38%+40.91%-173.73%

Profitability Metrics

Technical Analysis

Candela
Candela
Technical Analysis

ALNY is currently trading below key moving averages, indicating a bearish bias, yet momentum indicators like the MACD suggest a potential shift toward bullishness. The stock is consolidating within a range, showing signs of slowing down its decline but not yet confirming a sustained reversal. Key technical levels around $287.98 support and $318.3 resistance define the near-term trading range.

RSI
Hold
Neutral31

No extreme reading

03070100
Trend
Sell
Strong Downtrend

Price in downtrend

-36.7% from 200 SMA
ADX
Buy
Strong Trend26

Strong trend active

Strong
MA Cross
Sell
Below 50/200

50 below 200 - bearish

50
200

Key Technical Values

Price
$220.33
50 SMA
$286.56
150 SMA
$316.48
200 SMA
$348.05
52W High
$495.55
52W Low
$197.81

Price with Moving Averages

50-day, 150-day and 200-day simple moving averages

Price
50 SMA
150 SMA
200 SMA

Relative Strength Index

Momentum oscillator measuring speed and magnitude of price changes

RSI (14)

≤30 Oversold
≥70 Overbought
31Neutral

Earnings

Essentia
Essentia
Fundamental Analysis
NEUTRAL

Alnylam Pharmaceuticals (ALNY) operates as a leading biotech firm specializing in RNA interference therapeutics with a strong niche in rare genetic diseases. Despite a compressed valuation reflecting market skepticism, the company has maintained solid revenue growth driven by a premium, specialized product portfolio, though profit margins and earnings remain pressured by substantial R&D investments.

Latest Earnings

Q2 2026 Earnings (Jun 30, 2026)

Earnings Per Share (EPS)

Miss

Actual

$1.21

Estimated

$1.63

Surprise

$-0.42

Surprise %

-25.77%

Revenue

Miss

Actual

$1.29B

Estimated

$1.32B

Surprise

-$31.18M

Surprise %

-2.36%

Historical Earnings

 Q2 2026Q1 2026Q4 2025Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024
Earnings Per Share
EPS (Actual)$1.21$1.51$0.82$0.82$2.90$0.32$-0.01$0.06
EPS (Estimated)$1.63$0.87$1.16$1.16$0.56$-0.54$-0.89$-0.62
EPS Surprise-$0.42+$0.64-$0.34-$0.34+$2.34+$0.86+$0.88+$0.68
% Diff-25.8%+73.2%-29.3%-29.3%+416.9%+158.9%+98.9%+109.7%
Revenue
Revenue (Actual)$1.29B$1.17B$1.1B$1.1B$1.25B$773.69M$594.19M$593.17M
Revenue (Estimated)$1.32B$1.12B$1.15B$1.15B$959.4M$662.87M$585.14M$582.61M
Revenue Surprise-$31.18M+$51.66M-$52.08M-$52.08M+$289.63M+$110.82M+$9.05M+$10.56M
% Diff-2.4%+4.6%-4.5%-4.5%+30.2%+16.7%+1.5%+1.8%

Valuation

Valorem
Valorem
Valuation Analysis
FAIRLY VALUED

Alnylam Pharmaceuticals (ALNY) currently trades at a premium valuation compared to the broader biotech sector, supported by strong revenue growth and solid profitability metrics. Despite recent price target downgrades by some analysts, the consensus remains moderately positive with a potential upside of 40-60% based on intrinsic value estimates, reflecting confidence in its pipeline and market position amid near-term growth concerns.

Valuation Metrics

Price to Earnings

36.12

TTM

Price to Sales

6.14

TTM

Price to Book

21.68

TTM

Enterprise Value to EBITDA

25.25

TTM

Enterprise Value to Revenue

6.04

TTM

 Q2 2026Q1 2026Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024
Price to Earnings61.1853.3770.5159.69-159.85-153.42-90.50-79.03
Price to Sales31.0737.6747.9347.9954.6658.9351.0170.60
Price to Book29.6240.8966.63256.27168.75303.33451.031093.10
Enterprise Value to EBITDA162.10142.97171.73201.092331.783205.39-227.35-613.42
Enterprise Value to Revenue30.7337.3047.5947.8456.7661.7954.0173.85

Sentiment & Analyst Ratings

Pulse
Pulse
Sentiment Analysis
MIXED

Alnylam Pharmaceuticals (ALNY) sentiment is currently mixed due to a sharp stock decline after a disappointing Q2 2026 revenue miss and lowered full-year guidance, despite strong earnings per share and robust revenue growth in key products. Analysts broadly maintain a moderate buy consensus, reflecting confidence in Alnylam's long-term pipeline and market position, while social sentiment mirrors the recent cautious tone with concerns around product adoption and guidance normalization.

Analyst Recommendations

As of Aug 1, 2026
Strong SellSellHoldBuyStrong Buy
Buy
4.1 / 5.0
Based on 28 analyst ratings
Strong Sell
0
Sell
0
Hold
6
Buy
14
Strong Buy
8

Risk Assessment

Sentinel
Sentinel
Risk Assessment
MODERATE

Alnylam Pharmaceuticals (ALNY) currently presents a moderate financial risk profile supported by strong liquidity ratios and manageable leverage, although recent valuation pressures reflect clinical trial uncertainties and competitive risks. While liquidity is robust and debt levels are improving, key risks include regulatory milestones, pipeline trial outcomes, and market adoption challenges for its new drug. Analysts maintain a moderately positive outlook with cautious optimism given the recent share price volatility and reduced sales guidance.

Liquidity & Solvency

Current Ratio

3.05

Latest Quarter: Q2 2026

Quick Ratio

2.99

Latest Quarter: Q2 2026

Debt-to-Equity

0.94

Latest Quarter: Q2 2026

Debt-to-Assets

0.23

Latest Quarter: Q2 2026

 Q2 2026Q1 2026Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024
Liquidity Metrics
Current Ratio3.053.132.762.542.803.042.782.75
Quick Ratio2.993.062.712.492.752.982.712.69
Solvency Metrics
Debt-to-Equity0.941.181.625.5910.9323.5840.8984.26
Debt-to-Assets0.230.250.260.270.600.650.650.65

Liquidity Assessment

Current Ratio: 3.05(Strong)

Quick Ratio: 2.99(Strong)

The company has strong liquidity with sufficient short-term assets to cover liabilities.

Solvency Assessment

Debt-to-Equity: 0.94(Moderate)

Debt-to-Assets: 0.23(Low)

The company maintains a balanced capital structure with manageable debt levels.

Frequently Asked Questions about ALNY

AI Answers: Common Questions About ALNY

Get AI-powered answers to the questions investors ask most about Alnylam Pharmaceuticals, Inc.

ALNY is a good buy for long-term investors due to its leadership in RNAi therapeutics, steady mid-20% revenue growth, and promising pipeline. However, the current P/E ratio of 48.97 and recent guidance cuts suggest cautious entry, preferably on technical support near $288 or after positive catalysts.

Selling is not broadly recommended unless near-term technical breakdown below $288 support occurs or clinical setbacks arise. The stock’s strong fundamentals and pipeline warrant holding through volatility for most investors.

Key risks include clinical trial failures, regulatory delays, slower adoption of new products like Amvuttra, and valuation pressures from a premium P/E and EV/EBITDA multiples relative to biotech peers.

Analyst consensus price targets imply 40-60% upside from current levels near $272, with resistance around $310-$318 as key technical targets.

ALNY trades at a premium valuation with a P/E of 48.97 and elevated EV/EBITDA reflecting high growth expectations. Valuation is below historical peaks but above sector medians, justified by rapid revenue growth (~65% YoY) and improving earnings.

Fundamentals show steady revenue growth driven by specialized RNAi products, healthy gross margins above 70%, but negative net margins due to high R&D and SG&A expenses. Liquidity is strong with current ratio above 3.1 and improving debt metrics.

Technically, the stock is below key moving averages indicating bearish trend, but MACD bullish crossover and neutral RSI suggest potential momentum building. Support at $288 and resistance near $310-$318 define the near-term range.

Upcoming catalysts include clinical trial readouts, new indication approvals, and acceleration in sales growth of core RNAi therapies, which could drive re-rating and positive sentiment shifts.

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