AMGN AI Stock Analysis – Buy, Hold, or Avoid?

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Amgen Inc. (AMGN)

$367.60-11.67 (-3.08%) today

Open
$375.18
High
$377.09
Low
$361.40
Volume
2.59M
Mkt Cap
$198.16B
52W High
$391.29
AI Verdict
Confidence 73%
AMGNAmgen Inc.
AlphaCrew AI
HOLD
Overall
Summary

Amgen (AMGN) exhibits strong fundamental growth and profitability, with bullish technicals and a robust drug pipeline, but faces elevated financial risk from high leverage, patent cliffs, and mixed sentiment. The stock is fairly valued at current levels, with upside potential hinging on pipeline execution and risk mitigation. Investors should weigh the solid long-term outlook against near-term volatility and sector-specific headwinds.

By Timeframe
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HOLD
Short
HOLD
Medium
BUY
Long
Agent Signals
221
Fund
Tech
Val
Sent
Risk

Fundamentals

Essentia
Essentia
Fundamental Analysis
BULLISH

Amgen Inc. (AMGN) demonstrates robust financial health, with a consistent track record of revenue and earnings growth, supported by strong profitability and disciplined expense management. The company has posted notable earnings surprises and expanding margins, reflecting efficient operations and effective product portfolio management.

Financial Highlights

Q4 2024Q1 2025Q2 2025Q3 2025Q4 2025$0$2.5B$5.0B$7.5B$10.0BRevenue & Net Income ($)0%9%18%27%36%Net Margin (%)
  • Revenue
  • Net Income
  • Net Margin (%)

Revenue

$9.90B

8.91% YoY

Q4 2025

Net Income

$1.33B

112.60% YoY

Q4 2025

Net Margin

13.47%

Q4 2025

Growth Metrics

Revenue Growth YoY

8.91%

Latest Quarter: Q4 2025

Net Income Growth YoY

112.60%

Latest Quarter: Q4 2025

Revenue Per Share Growth YoY

9.22%

Latest Quarter: Q4 2025

EPS Growth YoY

111.11%

Latest Quarter: Q4 2025

Book Value Per Share Growth YoY

47.73%

Latest Quarter: Q4 2025

 Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024
Revenue9.9B9.6B9.2B8.1B9.1B8.5B8.4B7.4B
Revenue Growth YoY+8.91%+12.40%+9.29%+9.43%+10.86%+23.18%+20.07%+21.98%
Net Income1.3B3.2B1.4B1.7B627.0M2.8B746.0M-113.0M
Net Income Growth YoY+112.60%+13.64%+91.96%+1630.97%-18.25%+63.58%-45.90%-103.98%
EPS$2.47$5.98$2.66$3.22$1.17$5.27$1.39-$0.21
EPS Growth YoY+111.11%+13.47%+91.37%+1633.33%-18.18%+63.16%-46.12%-103.95%

Profitability Metrics

No profitability metrics available

Technical Analysis

Candela
Candela
Technical Analysis
BULLISH

AMGN is firmly in an advancing uptrend phase characterized by strong institutional accumulation and a golden cross with price trading well above its major moving averages. Recent price action shows consolidation near 52-week highs with bullish chart patterns like ascending triangles and rectangle breakouts suggesting further upside potential. Momentum indicators are generally positive, although volume divergence hints at caution around current resistance levels near $388-$390.

RSI
Hold
Neutral49

No extreme reading

03070100
Trend
Buy
Strong Uptrend

Price in uptrend

+17.9% from 200 SMA
ADX
Buy
Strong Trend27

Strong trend active

Strong
MA Cross
Buy
Above 50/200

50 above 200 - bullish

50
200

Key Technical Values

Price
$367.60
50 SMA
$351.93
150 SMA
$319.08
200 SMA
$311.90
52W High
$391.29
52W Low
$261.43

Price with Moving Averages

50-day, 150-day and 200-day simple moving averages

Price
50 SMA
150 SMA
200 SMA

Relative Strength Index

Momentum oscillator measuring speed and magnitude of price changes

RSI (14)

≤30 Oversold
≥70 Overbought
49Neutral

Earnings

Essentia
Essentia
Fundamental Analysis
BULLISH

Amgen Inc. (AMGN) demonstrates robust financial health, with a consistent track record of revenue and earnings growth, supported by strong profitability and disciplined expense management. The company has posted notable earnings surprises and expanding margins, reflecting efficient operations and effective product portfolio management.

Latest Earnings

Q4 2025 Earnings (Dec 31, 2025)

Earnings Per Share (EPS)

Beat

Actual

$5.29

Estimated

$4.73

Surprise

+$0.56

Surprise %

+11.84%

Revenue

Beat

Actual

$9.9B

Estimated

$9.47B

Surprise

+$421.98M

Surprise %

+4.45%

Historical Earnings

 Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024
Earnings Per Share
EPS (Actual)$5.29$5.64$6.02$4.90$5.31$5.58$4.97$3.96
EPS (Estimated)$4.73$5.02$5.28$4.27$5.04$5.11$4.98$3.88
EPS Surprise+$0.56+$0.62+$0.74+$0.63+$0.27+$0.47-$0.01+$0.08
% Diff+11.8%+12.4%+14.0%+14.8%+5.4%+9.2%-0.2%+2.1%
Revenue
Revenue (Actual)$9.9B$9.56B$9.17B$8.15B$9.09B$8.5B$8.39B$7.45B
Revenue (Estimated)$9.47B$8.97B$8.94B$8.06B$8.88B$8.5B$8.35B$7.45B
Revenue Surprise+$421.98M+$590.55M+$231.48M+$91.47M+$204.76M+$4.69M+$36.15M-$4.6M
% Diff+4.5%+6.6%+2.6%+1.1%+2.3%+0.1%+0.4%-0.1%

Valuation

Valorem
Valorem
Valuation Analysis
FAIRLY VALUED

Amgen (AMGN) presents a valuation profile that is moderately premium compared to the broader biotech sector but attractive relative to its direct peers. The stock trades with solid profitability and margin metrics, supported by steady revenue and earnings growth, although some valuation multiples reflect elevated expectations. Recent analyst consensus leans towards a cautious hold with moderate upside, reflecting balanced optimism about its growth pipeline and competitive risks.

Valuation Metrics

Price to Earnings

25.70

TTM

Price to Sales

5.39

TTM

Price to Book

22.88

TTM

Enterprise Value to EBITDA

13.04

TTM

Enterprise Value to Revenue

6.63

TTM

 Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024
Price to Earnings33.0911.8026.2224.2256.1715.2955.97-335.64
Price to Sales17.8315.8916.3920.5715.5120.3519.9120.37
Price to Book20.3815.7820.2227.0023.9722.9928.1930.21
Enterprise Value to EBITDA43.7333.3154.8552.9564.6042.5673.4095.60
Enterprise Value to Revenue22.4220.6121.6426.5320.8026.3926.2727.67

Sentiment & Analyst Ratings

Pulse
Pulse
Sentiment Analysis
MIXED

Amgen's sentiment landscape is mixed, with solid Q4 2025 earnings beats and bullish pipeline prospects tempered by cautious analyst outlooks and concerns about near-term sales declines. News coverage highlights strong financial results and growth guidance, but also points to competitive pressures and patent expirations that give investors pause. Retail sentiment shows engagement and momentum, yet there remains debate about valuation and growth sustainability.

Analyst Recommendations

As of Mar 1, 2026
Strong SellSellHoldBuyStrong Buy
Hold
3.4 / 5.0
Based on 33 analyst ratings
Strong Sell
1
Sell
2
Hold
17
Buy
9
Strong Buy
4

Risk Assessment

Sentinel
Sentinel
Risk Assessment
HIGH

Amgen faces moderate to high financial risk driven by elevated leverage and significant competitive pressures from biosimilars and generics impacting key revenue streams. While maintaining steady revenue guidance and promising drug pipeline developments offers some growth potential, regulatory and legal uncertainties alongside high debt levels represent material challenges. Investors should weigh these dynamics carefully given mixed liquidity signals and sector-relative risks.

Liquidity & Solvency

Frequently Asked Questions about AMGN

AI Answers: Common Questions About AMGN

Get AI-powered answers to the questions investors ask most about Amgen Inc.

Amgen is fairly valued at a P/E of 26.5 and EV/EBITDA of 13.3x, with strong earnings growth and expanding margins (gross margin 71%, net margin 20.9%). While the long-term outlook is positive, current price near $377 is close to resistance, and high leverage/patent risks suggest waiting for a pullback or breakout before buying aggressively.

Unless your risk tolerance is low or you need to rebalance, there is no urgent reason to sell: fundamentals remain strong, and technicals do not indicate a breakdown. However, if the stock fails to break above $390 or faces negative regulatory news, consider trimming exposure.

The biggest risks are Amgen’s high debt (debt/equity >6), declining liquidity (current ratio ~1.14, quick ratio <0.9), and exposure to biosimilar/generic competition on key drugs. Regulatory and legal uncertainties, including IRS tax disputes, could further pressure earnings and valuation.

Technical resistance is at $388-$390, with upside potential to $393-$400 if a breakout occurs. Analyst price targets range from $304 to $432, reflecting both upside from pipeline catalysts and downside from competitive/legal risks. Strong support lies at $348-$349.

Amgen is trading at a moderate premium to the sector (P/E 26.5, EV/EBITDA 13.3x, P/S 5.5x), but at a discount to direct peers, justified by its strong profitability and pipeline. The valuation is fair given current growth and risk profile, with limited room for multiple expansion absent new catalysts.

Fundamentally, Amgen is strong: revenue grew 9.9% YoY, FY25 EPS up 89%, gross margin at 71%, and net margin at 20.9%. The company consistently beats earnings estimates and maintains a diversified, innovative pipeline, though high leverage and reliance on a few blockbusters are concerns.

Technically, AMGN is in a strong uptrend above all major moving averages with a golden cross, RSI at 56.9 (neutral), and bullish chart patterns. However, price is consolidating near key resistance ($388-$390) with volume divergence, so a breakout or pullback will determine the next move.

Key catalysts include upcoming Phase 3 trial results (notably in obesity and oncology), regulatory approvals, and biosimilar launches. Earnings releases and resolution of legal/regulatory disputes could also drive significant price action.

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