INSM AI Stock Analysis – Buy, Hold, or Avoid?

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Insmed Incorporated (INSM)

$154.81-4.78 (-3.00%) today

Open
$159.49
High
$160.00
Low
$152.99
Volume
1.83M
Mkt Cap
$33.37B
52W High
$212.75
AI Verdict
Confidence 75%
INSMInsmed Incorporated
AlphaCrew AI
MIXED
Overall
Summary

Insmed (INSM) offers strong long-term growth potential in rare respiratory diseases, but faces significant near-term risks from recent clinical trial failures, persistent losses, and a premium valuation. Technicals show a sharp pullback and fading momentum, while sentiment and risk profiles are highly event-driven. Investors should be selective, with risk tolerance and time horizon dictating positioning.

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Short
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Medium
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Agent Signals
32
Fund
Tech
Val
Sent
Risk

Fundamentals

Essentia
Essentia
Fundamental Analysis
MIXED

Insmed Incorporated (INSM) exhibits significant top-line momentum with rapid revenue growth, but the company remains highly unprofitable due to substantial operating expenditures. The business continues to deliver strong gross margins yet faces persistent negative earnings and high cash burn, highlighting both its opportunity and inherent risks as a late-stage biotech firm.

Financial Highlights

Q4 2024Q1 2025Q2 2025Q3 2025Q4 2025-$400.0M-$200.0M$0$200.0M$400.0MRevenue & Net Income ($)-300%-250%-200%-150%-100%Net Margin (%)
  • Revenue
  • Net Income
  • Net Margin (%)

Revenue

$263.84M

152.62% YoY

Q4 2025

Net Income

-$328.49M

-39.46% YoY

Q4 2025

Net Margin

-124.50%

Q4 2025

Growth Metrics

Revenue Growth YoY

152.62%

Latest Quarter: Q4 2025

Net Income Growth YoY

-39.46%

Latest Quarter: Q4 2025

Revenue Per Share Growth YoY

111.69%

Latest Quarter: Q4 2025

EPS Growth YoY

-16.67%

Latest Quarter: Q4 2025

Book Value Per Share Growth YoY

116.99%

Latest Quarter: Q4 2025

 Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024
Revenue263.8M142.3M107.4M92.8M104.4M93.4M90.3M75.5M
Revenue Growth YoY+152.62%+52.36%+18.90%+22.94%+24.79%+18.15%+16.98%+15.77%
Net Income-328.5M-370.0M-321.7M-256.6M-235.5M-220.5M-300.6M-157.1M
Net Income Growth YoY-39.46%-67.79%-7.01%-63.33%-26.60%-38.75%-22.79%+1.67%
EPS-$1.54-$1.75-$1.70-$1.42-$1.32-$1.27-$1.94-$1.06
EPS Growth YoY-16.67%-37.80%+12.37%-33.96%-3.13%-14.41%-8.99%+9.40%

Profitability Metrics

Gross Margin

82.51%

TTM

Operating Margin

-94.64%

TTM

Net Margin

-124.50%

TTM

Return on Equity

-168.36%

TTM

Return on Assets

-62.87%

TTM

 Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024
Gross Margin82.51%79.37%73.86%77.08%74.96%77.34%76.79%76.88%
Operating Margin-94.64%-257.13%-291.28%-267.33%-220.61%-228.45%-319.80%-192.72%
Net Margin-124.50%-259.95%-299.48%-276.42%-225.53%-236.04%-332.75%-208.07%
Return on Equity (ROE)-44.45%-39.13%-25.74%-258.76%-82.54%-45.62%-774.41%33.80%
Return on Assets (ROA)-16.18%-17.29%-14.06%-15.94%-12.87%-11.88%-18.64%-16.35%

Technical Analysis

Candela
Candela
Technical Analysis
NEUTRAL

Unable to retrieve current internal technical indicator data due to API error, but based on available market data, INSM has pulled back sharply after approaching its 52-week high near $212. Price currently trades near $155, showing a notable decline of 3% in the last session. Further examination of live chart patterns, support, and resistance levels is necessary for a comprehensive trading perspective.

RSI
Hold
Neutral52

No extreme reading

03070100
Trend
Buy
Uptrend

Price in uptrend

+1.7% from 200 SMA
ADX
Hold
Weak/No Trend15

Range-bound market

Weak
MA Cross
Hold
Death Cross

Watching for cross

50
200

Key Technical Values

Price
$154.81
50 SMA
$150.54
150 SMA
$165.17
200 SMA
$152.16
52W High
$212.75
52W Low
$60.40

Price with Moving Averages

50-day, 150-day and 200-day simple moving averages

Price
50 SMA
150 SMA
200 SMA

Relative Strength Index

Momentum oscillator measuring speed and magnitude of price changes

RSI (14)

≤30 Oversold
≥70 Overbought
52Neutral

Earnings

Essentia
Essentia
Fundamental Analysis
MIXED

Insmed Incorporated (INSM) exhibits significant top-line momentum with rapid revenue growth, but the company remains highly unprofitable due to substantial operating expenditures. The business continues to deliver strong gross margins yet faces persistent negative earnings and high cash burn, highlighting both its opportunity and inherent risks as a late-stage biotech firm.

Latest Earnings

Q4 2025 Earnings (Dec 31, 2025)

Earnings Per Share (EPS)

Miss

Actual

$-1.54

Estimated

$-1.07

Surprise

$-0.47

Surprise %

-43.93%

Revenue

Beat

Actual

$263.84M

Estimated

$231.25M

Surprise

+$32.6M

Surprise %

+14.10%

Historical Earnings

 Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024
Earnings Per Share
EPS (Actual)$-1.54$-1.75$-1.70$-1.42$-1.32$-1.27$-1.94$-1.06
EPS (Estimated)$-1.07$-1.33$-1.30$-1.34$-1.17$-1.20$-1.24$-1.24
EPS Surprise-$0.47-$0.42-$0.40-$0.08-$0.15-$0.07-$0.70+$0.18
% Diff-43.9%-31.6%-30.8%-6.0%-12.8%-5.8%-56.5%+14.5%
Revenue
Revenue (Actual)$263.84M$142.34M$107.42M$92.82M$104.44M$93.43M$90.34M$75.5M
Revenue (Estimated)$231.25M$115.45M$104.13M$91.47M$102.08M$93.36M$87.95M$77.76M
Revenue Surprise+$32.6M+$26.9M+$3.29M+$1.36M+$2.36M+$64.13K+$2.39M-$2.26M
% Diff+14.1%+23.3%+3.2%+1.5%+2.3%+0.1%+2.7%-2.9%

Valuation

Valorem
Valorem
Valuation Analysis
OVERVALUED

Insmed Incorporated (INSM) currently trades at a premium valuation with strong analyst bullishness and significant upside potential reflected in price targets averaging around $212, about 33% above the current price. However, the company faces challenges including negative earnings, high cash burn, and recent clinical trial setbacks that weigh on its financial performance and risk profile. The valuation appears to factor in high growth expectations and pipeline prospects despite current profitability headwinds.

Valuation Metrics

Price to Earnings

-25.90

TTM

Price to Sales

55.03

TTM

Price to Book

44.76

TTM

Enterprise Value to EBITDA

-28.59

TTM

Enterprise Value to Revenue

55.45

TTM

 Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024
Price to Earnings-28.30-20.60-14.81-13.44-13.12-14.38-8.54-6.31
Price to Sales140.92214.24177.36148.65118.34135.74113.6052.54
Price to Book50.3132.2515.24139.1543.3126.23264.39-8.53
Enterprise Value to EBITDA-124.48-89.41-62.30-63.17-61.96-68.13-37.54-35.46
Enterprise Value to Revenue141.90217.12172.33158.41125.61143.26115.0762.80

Sentiment & Analyst Ratings

Pulse
Pulse
Sentiment Analysis
MIXED

Insmed (INSM) sentiment is currently mixed to cautiously optimistic. A recent Phase 2b trial failure for brensocatib triggered a sharp negative price reaction and insider selling, yet analyst consensus remains strongly bullish with significant upside price targets. Retail investors show predominantly positive social sentiment, reflecting confidence in long-term prospects despite near-term setbacks.

Analyst Recommendations

As of Apr 1, 2026
Strong SellSellHoldBuyStrong Buy
Buy
4.2 / 5.0
Based on 20 analyst ratings
Strong Sell
0
Sell
0
Hold
0
Buy
17
Strong Buy
3

Risk Assessment

Sentinel
Sentinel
Risk Assessment
HIGH

Insmed Inc. presents a complex risk profile characterized by strong liquidity but high leverage and significant operational risks due to recent clinical trial failures and regulatory/legal challenges. While it maintains supportive analyst sentiment with bullish price targets, the company faces ongoing profitability issues and substantial insider selling, indicating cautious investor sentiment. The financial health is adequate in the short term but long-term sustainability depends on successful pipeline execution and operational improvements.

Liquidity & Solvency

Current Ratio

3.83

Latest Quarter: Q4 2025

Quick Ratio

3.54

Latest Quarter: Q4 2025

Debt-to-Equity

1.04

Latest Quarter: Q4 2025

Debt-to-Assets

0.34

Latest Quarter: Q4 2025

 Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024
Liquidity Metrics
Current Ratio3.834.636.685.865.456.372.711.80
Quick Ratio3.544.346.335.445.125.992.531.61
Solvency Metrics
Debt-to-Equity1.040.790.5913.214.602.4135.53-2.95
Debt-to-Assets0.340.320.300.730.650.570.761.18

Liquidity Assessment

Current Ratio: 3.83(Strong)

Quick Ratio: 3.54(Strong)

The company has strong liquidity with sufficient short-term assets to cover liabilities.

Solvency Assessment

Debt-to-Equity: 1.04(High)

Debt-to-Assets: 0.34(Moderate)

The company has relatively high debt levels, which may increase financial risk in economic downturns.

Frequently Asked Questions about INSM

AI Answers: Common Questions About INSM

Get AI-powered answers to the questions investors ask most about Insmed Incorporated

INSM is not an obvious buy right now for most investors: it trades at a premium with a negative P/E (-24.11), high P/S, and is down 27% from its 52-week high. While long-term prospects are strong, recent technical weakness and a failed Phase 2b trial suggest waiting for stabilization or new positive catalysts before buying.

If you are a short-term trader or risk-averse, consider reducing exposure given technical weakness and deteriorating sentiment. However, long-term holders with high risk tolerance may want to hold through volatility, as the fundamental thesis remains intact if pipeline execution improves.

The biggest risks are clinical trial failures (as seen with brensocatib), persistent net losses (net margin below -200%), high cash burn, and substantial leverage (debt-to-equity ~1.04). Insider selling and high volatility further amplify downside risk.

Analyst price targets average $212 (about 33% above current price), with technical resistance near $160 and major support at $150 and $130. Upside to $210+ is possible if pipeline catalysts succeed, but downside to $64 is not out of the question if setbacks persist.

INSM is overvalued by traditional metrics: negative P/E, very high P/S and P/B, and negative EV/EBITDA. The premium reflects high growth expectations and pipeline optimism, but leaves little margin of safety if execution disappoints.

Fundamentally, INSM is strong on revenue growth (67% YoY), gross margins (>80%), and niche leadership, but weak on profitability, with deep net losses and dependence on external funding. Liquidity is solid short-term (current ratio >3.8), but long-term sustainability is unproven.

Technical analysis shows a sharp pullback from highs, fading momentum, and support near $150, with no clear bullish reversal. Traders should wait for stabilization or a confirmed bounce before entering.

Key catalysts include upcoming clinical trial readouts, regulatory decisions, and potential new product launches or label expansions. Earnings reports and updates on Arikayce/Brinsupri adoption will also be crucial for sentiment and price action.

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