PFE AI Stock Analysis – Buy, Hold, or Avoid?

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Pfizer Inc. (PFE)

$25.89+0.08 (+0.29%) today

Open
$25.82
High
$26.09
Low
$25.74
Volume
26.75M
Mkt Cap
$147.53B
52W High
$28.75
AI Verdict
Confidence 85%
PFEPfizer Inc.
AlphaCrew AI
HOLD
Overall
Summary

Pfizer presents a stable but unexciting investment profile, with fundamentals rebounding post-pandemic, a fair valuation, and a strong dividend yield, yet faces technical weakness and moderate risk from patent cliffs. Short-term technicals are bearish, but medium- and long-term prospects are supported by a resilient core business and pipeline progress. The stock is best suited for income-oriented or defensive investors seeking stability rather than aggressive growth.

By Timeframe
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Short
HOLD
Medium
HOLD
Long
Agent Signals
41
Fund
Tech
Val
Sent
Risk

Fundamentals

Essentia
Essentia
Fundamental Analysis
NEUTRAL

Pfizer demonstrates stabilizing fundamentals following recent earnings volatility, with a clear recovery trend emerging from prior pandemic-driven distortions. While the company has returned to positive earnings in the latest quarters, margin pressures and subdued long-term growth projections temper the outlook. Pfizer continues to deliver modestly above consensus expectations, signaling disciplined execution amidst sector-wide challenges.

Financial Highlights

Q1 2025Q2 2025Q3 2025Q4 2025Q1 2026-$6.0B$0$6.0B$12.0B$18.0BRevenue & Net Income ($)-10%0%10%20%30%Net Margin (%)
  • Revenue
  • Net Income
  • Net Margin (%)

Revenue

$14.45B

5.37% YoY

Q1 2026

Net Income

$2.69B

-9.40% YoY

Q1 2026

Net Margin

18.60%

Q1 2026

Growth Metrics

Revenue Growth YoY

5.37%

Latest Quarter: Q1 2026

Net Income Growth YoY

-9.40%

Latest Quarter: Q1 2026

Revenue Per Share Growth YoY

5.07%

Latest Quarter: Q1 2026

EPS Growth YoY

-10.10%

Latest Quarter: Q1 2026

Book Value Per Share Growth YoY

-0.54%

Latest Quarter: Q1 2026

 Q1 2026Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024
Revenue14.5B17.6B16.7B14.7B13.7B17.8B17.7B13.3B
Revenue Growth YoY+5.37%-1.16%-5.92%+10.31%-7.82%+21.91%+31.21%+2.12%
Net Income2.7B-1.6B3.5B2.9B3.0B403.0M4.5B24.0M
Net Income Growth YoY-9.40%-508.93%-20.84%+12025.00%-4.90%+112.06%+286.84%-98.97%
EPS$0.47-$0.29$0.62$0.51$0.52$0.07$0.79$0.00
EPS Growth YoY-10.10%-500.55%-21.45%+12042.86%-5.20%+112.14%+286.16%-98.98%

Profitability Metrics

Gross Margin

67.26%

TTM

Operating Margin

27.90%

TTM

Net Margin

18.60%

TTM

Return on Equity

8.37%

TTM

Return on Assets

8.96%

TTM

 Q1 2026Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024
Gross Margin67.26%69.97%74.95%64.29%71.65%73.01%60.85%62.06%
Operating Margin27.90%21.01%21.32%24.40%33.71%32.23%28.06%14.15%
Net Margin18.60%-9.39%21.26%19.86%21.63%2.27%25.27%0.18%
Return on Equity (ROE)2.98%-1.91%3.82%3.28%3.28%0.46%4.85%0.03%
Return on Assets (ROA)3.21%-1.98%4.01%3.45%3.47%0.45%4.92%0.03%

Technical Analysis

Candela
Candela
Technical Analysis
BEARISH

Pfizer (PFE) is currently in a technical downtrend with price trading below its 50-day and 150-day SMAs but just above the 200-day SMA. Momentum indicators are neutral to weak, and the stock appears to be in a topping phase characterized by increased volatility and distribution. This suggests caution, as the setup favors potential downside if key supports fail.

RSI
Hold
Neutral38

No extreme reading

03070100
Trend
Hold
Mixed

Mixed signals

+0.5% from 200 SMA
ADX
Hold
Weak/No Trend15

Range-bound market

Weak
MA Cross
Hold
Golden Cross

Watching for cross

50
200

Key Technical Values

Price
$25.87
50 SMA
$26.99
150 SMA
$26.07
200 SMA
$25.73
52W High
$28.75
52W Low
$21.97

Price with Moving Averages

50-day, 150-day and 200-day simple moving averages

Price
50 SMA
150 SMA
200 SMA

Relative Strength Index

Momentum oscillator measuring speed and magnitude of price changes

RSI (14)

≤30 Oversold
≥70 Overbought
38Neutral

Earnings

Essentia
Essentia
Fundamental Analysis
NEUTRAL

Pfizer demonstrates stabilizing fundamentals following recent earnings volatility, with a clear recovery trend emerging from prior pandemic-driven distortions. While the company has returned to positive earnings in the latest quarters, margin pressures and subdued long-term growth projections temper the outlook. Pfizer continues to deliver modestly above consensus expectations, signaling disciplined execution amidst sector-wide challenges.

Latest Earnings

Q1 2026 Earnings (Mar 29, 2026)

Earnings Per Share (EPS)

Beat

Actual

$0.75

Estimated

$0.72

Surprise

+$0.03

Surprise %

+3.88%

Revenue

Beat

Actual

$14.45B

Estimated

$13.84B

Surprise

+$610.81M

Surprise %

+4.41%

Historical Earnings

 Q1 2026Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024
Earnings Per Share
EPS (Actual)$0.75$0.66$0.87$0.78$0.92$0.63$1.06$0.60
EPS (Estimated)$0.72$0.57$0.63$0.58$0.67$0.47$0.61$0.46
EPS Surprise+$0.03+$0.09+$0.24+$0.20+$0.25+$0.16+$0.45+$0.14
% Diff+3.9%+16.4%+37.4%+34.5%+38.1%+33.6%+72.6%+31.0%
Revenue
Revenue (Actual)$14.45B$17.56B$16.65B$14.65B$13.72B$17.76B$17.7B$13.28B
Revenue (Estimated)$13.84B$16.85B$16.5B$13.56B$13.92B$17.35B$14.92B$12.96B
Revenue Surprise+$610.81M+$708.08M+$155.9M+$1.09B-$204.75M+$412.57M+$2.78B+$322.05M
% Diff+4.4%+4.2%+0.9%+8.1%-1.5%+2.4%+18.6%+2.5%

Valuation

Valorem
Valorem
Valuation Analysis
FAIRLY VALUED

Pfizer currently exhibits a valuation profile slightly below the broader healthcare sector average but above certain pharmaceutical peers, reflecting a balance between its established market presence and recent earnings challenges. The stock commands a moderate valuation premium supported by solid margins, consistent revenue streams, and an attractive dividend yield. Analyst sentiment is cautiously optimistic with a consensus hold rating and modest upside potential based on recent earnings beats and pipeline developments.

Valuation Metrics

Price to Earnings

19.67

TTM

Price to Sales

2.33

TTM

Price to Book

1.63

TTM

Enterprise Value to EBITDA

12.41

TTM

Enterprise Value to Revenue

3.32

TTM

 Q1 2026Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024
Price to Earnings14.70-21.479.5711.8412.1293.279.171665.57
Price to Sales10.948.068.149.4010.498.469.2612.04
Price to Book1.751.641.461.551.591.701.781.82
Enterprise Value to EBITDA42.34274.8334.6937.1940.2841.4131.6594.60
Enterprise Value to Revenue15.2811.8311.7713.5114.8511.9912.9717.13

Sentiment & Analyst Ratings

Pulse
Pulse
Sentiment Analysis
MIXED

Pfizer's sentiment landscape is mixed to cautiously positive, buoyed by a strong Q1 2026 earnings beat and reaffirmed full-year guidance, alongside progress in its product pipeline. However, dampening factors include concerns over early-stage trial halts and the challenges of transitioning beyond COVID-19 product revenues. Analyst sentiment leans toward a buy/hold consensus, while retail investors show divided views reflecting cautious optimism tempered by long-term growth uncertainties.

Analyst Recommendations

As of May 1, 2026
Strong SellSellHoldBuyStrong Buy
Hold
3.3 / 5.0
Based on 29 analyst ratings
Strong Sell
2
Sell
1
Hold
15
Buy
9
Strong Buy
2

Risk Assessment

Sentinel
Sentinel
Risk Assessment
MODERATE

Pfizer presents a moderate risk profile characterized by solid but somewhat stressed liquidity and leverage metrics. The company faces significant near-term revenue headwinds due to major patent expirations and declining COVID-19 product sales. However, ongoing pipeline developments and recent acquisitions offer potential growth avenues, balancing some downside risks for long-term investors.

Liquidity & Solvency

Current Ratio

1.25

Latest Quarter: Q1 2026

Quick Ratio

0.94

Latest Quarter: Q1 2026

Debt-to-Equity

0.72

Latest Quarter: Q1 2026

Debt-to-Assets

0.31

Latest Quarter: Q1 2026

 Q1 2026Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024
Liquidity Metrics
Current Ratio1.251.161.281.161.261.171.000.86
Quick Ratio0.940.870.970.850.960.920.730.60
Solvency Metrics
Debt-to-Equity0.720.780.660.700.680.720.720.78
Debt-to-Assets0.310.320.300.300.290.300.300.32

Liquidity Assessment

Current Ratio: 1.25(Adequate)

Quick Ratio: 0.94(Adequate)

The company has adequate liquidity but may face challenges in a downturn.

Solvency Assessment

Debt-to-Equity: 0.72(Moderate)

Debt-to-Assets: 0.31(Moderate)

The company maintains a balanced capital structure with manageable debt levels.

Frequently Asked Questions about PFE

AI Answers: Common Questions About PFE

Get AI-powered answers to the questions investors ask most about Pfizer Inc.

Pfizer is fairly valued at a P/E of 19.6 and offers a strong 6.7% dividend yield, but technicals are weak and the stock is near key support at $25.72. It is not an aggressive buy right now, but may appeal to income investors seeking stability over growth.

Unless technical support at $25.72 decisively breaks or fundamentals deteriorate, there is no urgent reason to sell; the stock remains fundamentally stable with improving margins and a fair valuation, but traders should monitor for a breakdown toward $22.

The biggest risks are major patent expirations between 2026-2028, which could materially impact revenue, a dividend payout ratio close to earnings coverage, and declining COVID-19 product sales. Sentinel rates overall risk as moderate, with debt-to-equity at 0.7 and current ratio at 1.25.

Technical resistance is at $27.06 (50-day SMA) and $28.75 (52-week high), with downside support at $25.72 (200-day SMA) and $22 if that fails. Analyst price targets average $28.85, implying modest upside from current levels.

Pfizer is fairly valued: its P/E of 19.6 is below the healthcare sector average but near its historical norm, and EV/EBITDA is slightly elevated due to stable earnings quality. The price-to-sales ratio is moderate, reflecting a mature, stable revenue base.

Fundamentally, Pfizer is solid with gross margins rebounding to 67%, net margin at 18.6% in Q1 2026, and consistent earnings beats. However, revenue growth is modest and long-term upside depends on pipeline execution.

Technically, the stock is in a downtrend, trading below key short-term moving averages and just above critical support at $25.72. RSI is near oversold at 35.22, suggesting risk of further downside unless support holds.

Key catalysts include upcoming earnings reports, pivotal pipeline trial results (especially in oncology and obesity), and any major product launches or regulatory approvals. Watch for news on patent settlements and dividend policy as well.

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